Erythema multiforme

• Immune-mediated, self-limiting mucocutaneous condition
• Skin eruption of various morphologies (hence the name): macules, papules, vesicles, targetoid lesions (central dusky area of epidermal necrosis surrounded by lighter oedematous margin)
• Associated with infections (especially Mycoplasma pneumoniae, HSV), drugs (sulfa drugs, beta lactams, phenytoin)

• Often not required
• Withdraw/stop offending agents or treat the underlying cause
• Supportive care: oral antihistamine and/or topical steroids if pruritus and pain
• Fluid and nutritional replacements if severe/reduced oral intake