Primary Biliary Cholangitis

• Autoimmune disorder characterized by destruction of the intrahepatic ducts
• Most commonly presents among middle-aged women with other autoimmune conditions

Signs and Symptoms

• Presents with progressive jaundice, pruritis, vitamin ADEK deficiency

Investigation

• ↑ ALP, ↑ bilirubin, ↑ cholesterol, antimitochondrial antibody +ve
• Liver biopsy

Management

• Cholestyramine for pruritus
• Ursodeoxycholic acid may slow the progression of the disease
• Liver transplantation

Reference: First-Aid for the USMLE Step 2 (10th Edition)