Non-alcoholic fatty liver disease

• Steatosis of hepatocytes which leads to liver injury
• Some patients may progress to have non-alcoholic steatohepatitis (NASH)
• ↑ risk of liver fibrosis and cirrhosis
• Associated with insulin resistance and metabolic syndrome

Investigation

• Diagnosis of exclusion
• Liver biopsy may show steatosis or steatohepatitis

Management

• Lifestyle measures: weight loss, diet and exercise
• If non-alcoholic steatohepatitis → consider vitamin E and pioglitazone

Reference: First-Aid for the USMLE Step 2 (10th Edition)